Noun
1. a serious (sometimes fatal) infection of rodents caused by Yersinia pestis and accidentally transmitted to humans by the bite of an infected rat flea (especially bubonic plague)
2. any epidemic disease with a high death rate
3. a swarm of insects that attack plants;
"a plague of grasshoppers"4. any large scale calamity (especially when thought to be sent by God)
5. an annoyance;
"those children are a damn plague"